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The article focuses on the use of corticosteroids in the treatment of community-acquired pneumonia (CAP). Topics include the conflicting evidence on the efficacy of corticosteroids with the results of a systematic review and meta-analysis of 16 trials;and the potential benefits and risks associated with corticosteroid use which will decrease the need for mechanical ventilation, with a higher rate of hospital readmission.
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The article discusses the task of radiologic technologists to know clotting disorders and image them best. Topics covered include the various symptoms and blood clots of patients with thrombotic disorders, and medical imaging's beneficial indication of the severity and blood clots' location in the patient's circulatory system, and support for accurate diagnosis and appropriate treatment. Also noted is the boost for positive patient outcomes when the health care team works together.
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The article presents a discussion on recognizing criterias for COVID-19 associated hyper inflammation by comparing two cohort studies.
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The article presents highlights from this issue of the publisher. Topics include information on Systemic lupus erythematosus and its response to Rituximab, durable treatment for Antineutrophilic cytoplasmic antibody associated vasculitis, and earlier recognition of immune checkpoint inhibitors induced inflammatory arthritis.
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George Winter provides an overview of recently published articles that are of interest to practice nurses. Should you wish to look at any of the papers in more detail, a full reference is provided.
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Introduction: Trigeminal neuralgia (TN) is among the most painful disorders of the orofacial region. Although TN has many possible etiologies, such as nerve compression, recently published evidence suggests that TN, or its exacerbations, may be the result of viral infections in the head and neck. This case presents clinical findings from a TN patient experiencing virally-induced exacerbations treated with intravenous (IV) magnesium sulfate and oral anti-inflammatories who was previously non-responsive to first-line pharmaceuticals. Methods: AM is a 51-year-old cis-female with a four-year history of TN caused by vascular encroachment of the trigeminal nerve and exacerbated by episodes of viral sinusitis and COVID-19. AM presented to the National University of Natural Medicine clinic in May 2019 and again in April 2022. After screening for contraindications, she was started on an IV Myer's push with an elevated dose of magnesium sulfate and oral anti-inflammatories: curcumin and omega-3. Results: Since her second presentation to our clinic in April 2022, the patient has undergone 11 treatments and reports significant benefit in pain and quality of life. Despite the initial MRI revealing vascular encroachment on her trigeminal nerve she experienced benefit from her treatment regimen and denied a neurosurgical consultation and repeat MRI. Conclusion: This study contributes to a growing body of literature suggesting that cranial neuralgias may be exacerbated by orofacial or upper-respiratory viral infections and that TN specifically may be well managed with IV nutrient therapy and oral anti-inflammatories. Given the paucity of successful treatment strategies, exploring cost-effective treatments with low side effect profiles is a worthwhile approach to improving clinical outcomes in patients with TN.
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Introduction: Covid-19 is a new respiratory disease that is the cause of an acute infection characterized by a progressive epidemiological picture. On the other hand, it will depend on the stage of the disease in which the patient is and the presence of physiological sequelae or acquired comorbidities, being these factors responsible for altering the quality of life and its relationship in the health field, affecting not only the physiological level but also other alterations such as the physical and mental state and the subjective impression of the state of the disease in the patient. Objective: To determine the quality of life of post Covid-19 patients. Materials and methods: A descriptive, cross-sectional study was carried out with a sample of 24 patients who signed the informed consent prior to the application of the evaluation. A section with sociodemographic variables was included and the Saint George questionnaire was applied for quality of life. Finally, the data analysis was compiled in Excel and SPSS software. Results: It was found that 83.3% of the post-covid-19 patients had a "good" quality of life health;the most impaired dimension was "Impact," with a mean of 24.3 ± 9.90, standing out from the other categories. Similarly, it was shown that 21% of the population was diagnosed with diseases after acquiring the virus, but they fall within a range of "good" quality of life without limitations in the dimensions of the questionnaire. Conclusion: Quality of life can become an important factor in the study of health. However, the percentage of the study population does not fall within a poor quality of life. However, it is essential to mention the correlation between Covid-19 and the sociodemographic variables associated with a negative effect on the quality of life according to the Saint George questionnaire evaluation and the degree of the disease in the patient. Introducción: El covid-19 es una nueva enfermedad respiratoria que es causante de una infección aguda caracterizada por un cuadro epidemiológico progresivo. Por otra parte, dependerá del estadio de la enfermedad en la que se encuentra el paciente y la presencia de secuelas fisiológicas o comorbilidades adquiridas, siendo estos factores los responsables de alterar la calidad de vida y su relación en el ámbito salud afectando no solo a nivel fisiológico si no que esta estará ligada a otras alteraciones como el estado físico, mental y la impresión subjetiva del estado de la enfermedad en el paciente. Objetivo: Determinar la calidad de vida de los pacientes post Covid-19. Materiales y métodos: Se realizó un estudio descriptivo, transversal, con una muestra de 24 pacientes los cuales firmaron el consentimiento informado previo a la aplicación de la evaluación. En ella se adjuntó una sección con variables sociodemográficos y para la calidad de vida se aplicó el cuestionario Saint George. Al finalizar, el análisis de datos se recopilo en la base de datos de Excel y software SPSS. Resultados Se encontró que los pacientes post covid-19 presenta una calidad de vida en relación a la salud "buena" en un-83,3%, la dimensión más perjudicada fue el "Impacto" con una media de 24,3 ± 9,90 sobresaliendo de las otras categorías. De igual forma, se demostró que dentro de la población el 21% se diagnostico con enfermedades posterior de haber adquirido el virus, pero se adentran dentro de un rango de "buena" calidad de vida sin limitaciones en las dimensiones del cuestionario. Conclusión: La calidad de vida puede llegar a ser un factor importante de estudio en la salud, sin embargo, el porcentaje de la población de estudio no se enmarca dentro de una calidad de vida mala. Sin embargo, es imprescindible mencionar la correlación del Covid-19 y las variables sociodemográficas asociadas a un efecto negativo en la calidad vida según la evaluación del cuestionario Saint George y el grado de la enfermedad en el paciente.
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Annotation: The causes of the development of cerebrovascular diseases in COVID-19 may be a significant deterioration in the rheological properties of blood, activation of hemostasis, changes in the atrombogenic properties of the vascular wall endothelium. Thrombocytopenia and elevated levels of fibrinogen, D-dimer and coagulation factor VIII are most often observed in COVID-19, Changes in the indicators of neurobiomarkers, namely antibodies to gliadin- fibrillar acid protein (GFAP), S-100 protein, to serotonin and dopamine receptors in CHEM indicate the severity of this disease. The aim of the study was to study the features of neurological and biochemical parameters in patients with CHEM who had a coronavirus infection, to assess the number and prognostic value of markers of brain damage: antibodies to GFAP, serotonin, dopamine receptors and S-100 protein.
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To observe the effects of COVID-19 infection on ANS function over a follow-up period in young adults. Observational prospective case-control study. Subjects were evaluated at baseline and in a follow-up visit six weeks following the first shot of SARS-CoV-2 immunization. Private Physical Therapy ambulatory. Male and female subjects aged 20-40 years with, a diagnosis of mild or moderate clinical COVID-19 with a positive PCR test and slight clinical symptoms, and who were not admitted to intensive care unit. Participants were recruited after a minimum of 15 and a maximum of 120 days of diagnosis (PCOV). An age-matched heathy control group (CG) that was negative for COVID-19 was also recruited. Autonomic nervous system function was measured through heart rate variability (HRV). Heart rate was recorded beat-to-beat to evaluate cardiac autonomic modulation. We used a cardio-frequency meter (Polar RS800CX). Participants were equipped with a chest strap and monitor and remained at rest for 25 minutes. Sympathetic and Parasympathetic indexes through HRV. 57 subjects were evaluated at baseline. After 19 exclusions, 38 subjects with complete data were included in the baseline analysis where 18 subjects were in CT and 20 in the PCOV group. Regarding sympathetic nervous system activity, there was no difference between baseline and follow-up moments within CT or PCOV groups (p>0.05). For intergroup analysis, we observed that PCOV group presents significant higher reductions in sympathetic activity over time when compared to CT demonstrated by HR (p=0.0088) and SNS index (p=0.0068). Observations of parasympathetic nervous system activity reveals a statistical increase between baseline and follow up in Mean RR (p=0.0312) and pNN50 (p=0.0312) for PCOV group. The intergroup analysis revealed that PCOV group presented a significant higher increase in parasympathetic activity overtime demonstrated by mean RR (-44.54±32.38 vs. 60.36±55.35;p= 0.0097) and PNS index (-0.32±0.20 vs. 0.54 ± 0.35;p= 0.0091) when compared to CT. Sympathetic activity decreased in PCOV after infection and over the follow up period. Authors declare no conflicts.
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Objective: This study was conducted to compare sleep disturbances between women with and without a history of Coronavirus disease-2019 (COVID-19) infection. Materials and Methods: In this descriptive study, the "Pittsburgh Sleep Quality Index" was used to evaluate sleep problems. The research sample was calculated as 120: 1. group 60 (with a history of COVID-19) and 2. group 60 (without a history of COVID-19) using the G*Power 3.1 method. A total of 141 women were interviewed in case of data loss. Due to the ongoing pandemic, the forms were filled in via google form in the social media environment. The data were analyzed with Statistical Package for Social Sciences for the Windows 22.0 program. Results: The mean age of the women involved in the study was 22.241±6.593 (min: 18, max: 58). Women with a history of COVID-19 experience occasional sleep problems several times a week and have difficulty falling asleep. Statistically significant differences were found between the sleep quality of women with and without a history of COVID-19. Subjective sleep quality, sleep latency, habitual sleep efficiency, use of sleeping medication, daytime dysfunction, and total sleep quality scores were found to be higher in women with a history of COVID-19. Conclusion: Sleep quality is lower in women with a history of COVID-19. During the COVID-19 pandemic, sleep quality should be evaluated, and sleep problems should be identified and treated within a short period. It is recommended to develop methods of coping with anxiety and stress experienced, especially during the COVID-19 pandemic and to raise awareness on this issue among people with a COVID-19 history. Amaç: Bu araştırmanın amacı Koronavirüs hastalığı-2019 (COVID-19) geçiren ve geçirmeyen kadınlar arasındaki uyku bozukluklarının karşılaştırılmasıdır. Gereç ve Yöntem: Tanımlayıcı olarak planlanan bu çalışmada uyku problemlerinin değerlendirilmesi için "Pittsburgh Uyku Kalitesi Índeksi" kullanılmıştır. Araştırma örneklemi G*Power 3.1 yöntemiyle birinci grup 60 (COVID-19 geçiren), ikinci grup 60 (COVID-19 geçirmeyen) olmak üzere 120 olarak belirlenmiştir. Kayıplar göz önüne alınarak toplamda 141 kadın ile görüşülmüştür. Pandeminin devam etmesi sebebi ile formlar sosyal medya ortamında Google form ile doldurulmuştur. Araştırma verileri Statistical Package for Social Sciences for Windows 22.0 programı ile analiz edilmiştir. Bulgular: Çalışmaya katılan kadınların yaş ortalaması 22,241±6,593 (min: 18, maks: 58) idi. COVID-19 geçiren grup arasında uyku problemlerini haftada birkaç kez sıklıkla ve ara sıra görüldüğü, kadınların uykuya dalmada zorluk yaşadıkları tespit edildi. COVID-19 geçiren ve geçirmeyen kadınlar arasında uyku kalitesinin değerlendirilmesi sonucunda gruplar arasında istatistiksel olarak anlamlı farklar tespit edildi. COVID-19 geçiren kadınlar arasında öznel uyku kalitesi, uyku latansı, alışılmış uyku etkinliği, uyku ilacı kullanımı, gündüz uyku işlev bozukluğu ve toplam uyku kalitesi puanlarının daha yüksek olduğu tespit edildi. Sonuç: COVID-19 geçiren kadınlar arasında uyku kalitesi daha düşüktür. COVID-19 sürecinde uyku kalitesinin değerlendirilmesi ve uyku problemlerinin kısa sürede belirlenerek tedavi edilmesi önemlidir. Özellikle COVID-19 sürecinde yaşanılan kaygı ve stresle baş etme yöntemlerinin geliştirilmesi ve tanı alan kişilerin bu konuda da farkındalıklarının sağlanması önerilmektedir.
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Objective: This study determined whether children have sleep disorders during the Coronavirus disease-2019 (COVID-19) pandemic restriction process, and if they do, to determine in which areas they have problems with sleep, as well as to examine the relationship of sleep disorder with chronotype and coronavirus anxiety. Materials and Methods: In April-November 2020, 98 patients attending Kocaeli University Child Psychiatry clinics and attending primary school 1-4th grade were recruited. "Sociodemographic Form", "Child Sleep Habits Questionnaire", and "Children's Chronotype Questionnaire" were applied to the parents. The short form of the "Coronavirus Anxiety Scale" and the information form about the pandemic process were applied to the children. Results: According to the sleep habits questionnaire, 70.4% of the group had clinically significant sleep problems. The most common sleep disorders observed in our study;are bedtime resistance, delayed falling asleep, and nighttime awakenings. A significant relationship was found between physical illness in the family (p=0.019), smoking (p=0.032), sleep pattern change during the pandemic (p=0.002), sleep change of the mother (p=0.006) and/or father (p=0.035), change in appetite (p=0.010), and sleep disorder. According to the chronotype scale, 66 children were morning and children's anxiety toward coronavirus was low. Conclusion: Our study shows that sleep disturbance in children is marked during the pandemic period, but this is due to changes in sleep patterns and parents' sleep rather than problems related to anxiety or chronotype associated with the pandemic. It will be useful to question these factors and make arrangements in this direction when evaluating the sleep-related problems of patients who apply to outpatient clinics. Amaç: Bu çalışmada, Koronavirüs hastalığı-2019 (COVID-19) pandemisi kısıtlama sürecinde çocukların uyku bozukluğu yaşayıp yaşamadığının, eğer yaşıyorlarsa uyku ile ilgili hangi alanlarda sorun yaşadıklarının saptanması, ayrıca uyku bozukluğunun kronotip ve Koronavirüs anksiyetesi ile ilişkisinin incelenmesi amaçlanmıştır. Gereç ve Yöntem: Nisan-Kasım 2020 tarihleri arasında Kocaeli Üniversitesi Çocuk ve Ergen Psikiyatri polikliniklerine başvuran;ilkokul 1-4. sınıfa giden 98 hasta çalışmaya dahil edilmiştir. Ebeveynlere "Sosyodemografik Bilgi Formu", "Çocuk Uyku Alışkanlıkları Anketi", "Çocukluk Dönemi Kronotip Anketi";çocuklara ise "Koronavirus Anksiyete Ölçeği Kısa Formu" ve pandemi süreci ile ilgili beş maddeden oluşan bilgi formu uygulanmıştır. Bulgular: Uyku alışkanlıkları anketi toplam puanına bakıldığında, grubun %70,4'ünün klinik olarak anlamlı düzeyde uyku sorunu yaşadığı saptanmıştır. Çalışmamızda gözlenen en yaygın uyku bozuklukları;yatma zamanı direnci, uykuya dalmanın gecikmesi ve gece uyanmalarıdır. Ailede fiziksel hastalık (p=0,019), sigara kullanımı (p=0,032), pandemide uyku düzen değişikliği (p=0,002), annenin uyku değişimi (p=0,006), babanın uyku değişimi (p=0,035), ve iştah değişimi (p=0,010) ile uyku bozukluğu arasında anlamlı ilişki saptanmıştır. Kronotip ölçeğine göre 66 çocuğun sabahçı, 31 çocuğun ara form, bir çocuğun ise akşamcı olduğu gözlenmiştir. Çocukların Koronavirüse yönelik anksiyetesinin düşük olduğu saptanmıştır. Sonuç: Çalışmamız, çocuklarda pandemi döneminde uyku bozukluğunun belirgin düzeyde olduğunu ancak bu durumun pandemi ile ilişkili anksiyete ya da kronotip ile ilgili sorunlardan çok, uyku düzenlerindeki değişiklik ve ebeveynlerin uykusundaki değişimlerden kaynaklandığını göstermektedir. Polikliniklere başvuran hastaların uyku ile ilgili sorunları değerlendirilirken bu faktörlerin sorgulanması ve bu yönde düzenlemeler yapılması yararlı olacaktır.
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For the third year COVID-19 pandemic is still a global health challenge, despite the availability of vaccines and protection methods, treatment protocols still being updated continuously to observe the optimum management for patients. Cyclooxegynase (COX) enzymes are involved in inflammation and thrombosis related to COVID-19. COX-Thromboxane2 pathway is one of the important pathways that results in thrombus formation. In this study the COX activity level changes were measured by ELISA technique in COVID-19 plasma samples that treated with SIRT1 activators resveratrol and linear BAS SIRT1 aptamer, a significant lowering in COX activity was observed with promising potential atrithrombotic action in COVID-19 to be further investigated in future.
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The article focuses on long COVID-19 and its impact on healthcare workers;other topics including the variety of symptoms and manifestations of the condition, the uncertainty surrounding the number of healthcare workers affected, and the risk of worsened symptoms upon reinfection.
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Background: The purpose of this case study is to describe how post-exertional symptom exacerbation (PESE), a hallmark of long COVID, may affect the clinical course of physical therapy. Physical therapists can provide patient education and activity guidance to individuals with long COVID to improve clinical outcomes. Case Description: The patient was a 39-year-old female with a 20-year history of bilateral knee pain. Following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the patient developed PESE and increased bilateral knee joint effusion and pain, affecting her ability to perform cognitive tasks and walk, respectively. Outcomes: Following 8 weeks of intervention, the patient's Lower Extremity Functional Scale score improved from 35/80 to 59/80 and numeric pain rating scale decreased from 7/10 to 4/10 at maximum, but she experienced an apparent PESE relapse. Discussion: Post-exertional symptom exacerbation can affect multiple body systems, which may affect a patient's ability to participate in physical therapy. Clinical Relevance: Physical therapy management of individuals with long COVID must include monitoring during and after exertion for signs and symptoms of PESE.
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Dogs can detect human stress... Children with COVID-19 at higher risk of T1D... ED-ICU not associated with substantially increased costs... Strategies to reduce pediatric deaths by guns... Electronic gaming and pediatric dysrhythmias
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The article reports on the findings of a study conducted by researchers at Washington University School of Medicine revealing that people who tested positive for COVID-19 are more at risk of neuropathy.